Drug interactions
Calcium chloride + Moxifloxacin
Severity: Moderate
Calcium chloride and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium can bind moxifloxacin in the gut and reduce its absorption, potentially causing subtherapeutic antibiotic levels. Intravenous calcium chloride does not share this absorption interaction.
What this interaction means in plain words
Calcium chloride and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of moxifloxacin by calcium (a divalent cation) in the gastrointestinal tract, reducing absorption.
What to do
Separate oral moxifloxacin from oral calcium by at least 4 hours before or 8 hours after as labeled. No separation is needed for intravenous calcium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Calcium chloride with Moxifloxacin?
MediHelp rates the interaction as moderate. Calcium chloride and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium can bind moxifloxacin in the gut and reduce its absorption, potentially causing subtherapeutic antibiotic levels. Intravenous calcium chloride does not share this absorption interaction.
How serious is the interaction between Calcium chloride and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral moxifloxacin from oral calcium by at least 4 hours before or 8 hours after as labeled. No separation is needed for intravenous calcium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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