Drug interactions
Calcium citrate + Gemifloxacin
Severity: Moderate
Calcium citrate and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium citrate taken by mouth can bind gemifloxacin in the gastrointestinal tract and reduce its absorption. This may lead to lower antibiotic exposure and reduced effectiveness.
What this interaction means in plain words
Calcium citrate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of gemifloxacin by calcium cations, impairing gastrointestinal absorption.
What to do
Give gemifloxacin at least 2 hours before or 3 hours after calcium citrate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Calcium citrate with Gemifloxacin?
MediHelp rates the interaction as moderate. Calcium citrate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium citrate taken by mouth can bind gemifloxacin in the gastrointestinal tract and reduce its absorption. This may lead to lower antibiotic exposure and reduced effectiveness.
How serious is the interaction between Calcium citrate and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gemifloxacin at least 2 hours before or 3 hours after calcium citrate.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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