Drug interactions
Calcium citrate + Hydrochlorothiazide-lisinopril
Severity: Moderate
Calcium citrate and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide lowers urinary calcium loss, so calcium citrate supplements can contribute to elevated serum calcium. Citrate is also an alkalinizing salt, so alkalosis is possible with high intake.
What this interaction means in plain words
Calcium citrate and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides enhance distal tubular calcium reabsorption, reducing renal calcium clearance.
What to do
Monitor serum calcium periodically, especially with high supplement doses or renal impairment. Reduce the calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Calcium citrate with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Calcium citrate and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide lowers urinary calcium loss, so calcium citrate supplements can contribute to elevated serum calcium. Citrate is also an alkalinizing salt, so alkalosis is possible with high intake.
How serious is the interaction between Calcium citrate and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high supplement doses or renal impairment. Reduce the calcium dose if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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