Drug interactions
Calcium citrate + Moxifloxacin
Severity: Moderate
Calcium citrate and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium citrate supplements can bind oral moxifloxacin in the gut and decrease its absorption, risking reduced antibacterial effect.
What this interaction means in plain words
Calcium citrate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of moxifloxacin by calcium (a divalent cation) in the gastrointestinal tract, reducing absorption.
What to do
Take moxifloxacin at least 4 hours before or 8 hours after calcium citrate. Consider holding the supplement during short antibiotic courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Calcium citrate with Moxifloxacin?
MediHelp rates the interaction as moderate. Calcium citrate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium citrate supplements can bind oral moxifloxacin in the gut and decrease its absorption, risking reduced antibacterial effect.
How serious is the interaction between Calcium citrate and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take moxifloxacin at least 4 hours before or 8 hours after calcium citrate. Consider holding the supplement during short antibiotic courses.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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