Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Papaverine
Severity: Moderate
Calcium / magnesium / potassium / sodium oxybates and Papaverine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates cause marked CNS and respiratory depression. Papaverine has only modest sedative effects, so any additive impact is likely small and poorly documented.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Papaverine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive CNS depression; papaverine's sedative effect is weak and the interaction is largely theoretical.
What to do
Monitor for excessive sedation and respiratory depression when starting the combination, and counsel patients to avoid other CNS depressants and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
- Iloprost + Papaverine Moderate
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Papaverine?
MediHelp rates the interaction as moderate. Calcium / magnesium / potassium / sodium oxybates and Papaverine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybates cause marked CNS and respiratory depression. Papaverine has only modest sedative effects, so any additive impact is likely small and poorly documented.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Papaverine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression when starting the combination, and counsel patients to avoid other CNS depressants and alcohol.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Carbidopa-entacapone-levodopa. The full list is on the Papaverine page.
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