Drug interactions
Iloprost + Papaverine
Severity: Moderate
Iloprost and Papaverine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator and papaverine also relaxes vascular smooth muscle, so together they can cause additive hypotension. The risk matters most with intravenous iloprost.
What this interaction means in plain words
Iloprost and Papaverine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Papaverine belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin receptor agonism (iloprost) and phosphodiesterase inhibition (papaverine).
What to do
Monitor blood pressure and heart rate during iloprost infusion. Temporarily stop or reduce the other vasodilator, or lower the iloprost dose, if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloprost and Papaverine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Papaverine?
MediHelp rates the interaction as moderate. Iloprost and Papaverine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator and papaverine also relaxes vascular smooth muscle, so together they can cause additive hypotension. The risk matters most with intravenous iloprost.
How serious is the interaction between Iloprost and Papaverine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during iloprost infusion. Temporarily stop or reduce the other vasodilator, or lower the iloprost dose, if hypotension occurs.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
