Drug interactions
Givinostat + Papaverine
Severity: Major
Givinostat and Papaverine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is associated with QTc prolongation. Papaverine can affect cardiac conduction and has been reported to prolong the QT interval, so combined use may add to arrhythmia risk, including torsades de pointes.
What this interaction means in plain words
Givinostat and Papaverine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Papaverine belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Avoid the combination where possible; if it is necessary, obtain a baseline ECG and repeat during therapy, and correct potassium and magnesium. Hold givinostat if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Papaverine
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
- Iloprost + Papaverine Moderate
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Papaverine?
MediHelp rates the interaction as major. Givinostat and Papaverine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat is associated with QTc prolongation. Papaverine can affect cardiac conduction and has been reported to prolong the QT interval, so combined use may add to arrhythmia risk, including torsades de pointes.
How serious is the interaction between Givinostat and Papaverine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, obtain a baseline ECG and repeat during therapy, and correct potassium and magnesium. Hold givinostat if QTc becomes markedly prolonged.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Bretylium, Calcium / magnesium / potassium / sodium oxybates, Carbidopa-entacapone-levodopa. The full list is on the Papaverine page.
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