Drug interactions
Canagliflozin-metformin + Chlorothiazide
Severity: Moderate
Canagliflozin-metformin and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can raise blood glucose and blunt the effect of antidiabetic therapy. Combined diuretic effects with canagliflozin may also increase volume depletion and affect renal function, which matters for metformin safety.
What this interaction means in plain words
Canagliflozin-metformin and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Chlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides impair insulin secretion and glucose tolerance (partly via hypokalemia), opposing antidiabetic effects; additive volume depletion also occurs with SGLT2 inhibition.
What to do
Monitor blood glucose, renal function, electrolytes and volume status, and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Canagliflozin-metformin with Chlorothiazide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide can raise blood glucose and blunt the effect of antidiabetic therapy. Combined diuretic effects with canagliflozin may also increase volume depletion and affect renal function, which matters for metformin safety.
How serious is the interaction between Canagliflozin-metformin and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, renal function, electrolytes and volume status, and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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