Drug interactions
Canagliflozin-metformin + Desipramine
Severity: Minor
Canagliflozin-metformin and Desipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been associated with altered glucose handling, and hypoglycemia has been reported with some of them in diabetic patients. Any effect with metformin-based therapy is small and inconsistent.
What this interaction means in plain words
Canagliflozin-metformin and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Desipramine belongs to Central Nervous System.
Why it happens
Possible modest additive glucose-lowering effect; the mechanism is not well established.
What to do
No routine action is needed; check blood glucose if the patient reports symptoms of hypoglycemia or glycemic control changes after starting or stopping the antidepressant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Desipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Desipramine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been associated with altered glucose handling, and hypoglycemia has been reported with some of them in diabetic patients. Any effect with metformin-based therapy is small and inconsistent.
How serious is the interaction between Canagliflozin-metformin and Desipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check blood glucose if the patient reports symptoms of hypoglycemia or glycemic control changes after starting or stopping the antidepressant.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
