Drug interactions
Canagliflozin-metformin + Famotidine
Severity: Minor
Canagliflozin-metformin and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is renally secreted through cationic transport pathways and may modestly raise metformin exposure. Clinically relevant effects are uncommon at usual doses.
What this interaction means in plain words
Canagliflozin-metformin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Possible competition for renal tubular cationic transporters (OCT2/MATE) reduces metformin clearance.
What to do
No dose change is usually needed; be mindful of renal function and glycemic response in patients with impaired kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Canagliflozin-metformin with Famotidine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine is renally secreted through cationic transport pathways and may modestly raise metformin exposure. Clinically relevant effects are uncommon at usual doses.
How serious is the interaction between Canagliflozin-metformin and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; be mindful of renal function and glycemic response in patients with impaired kidney function.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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