Drug interactions
Canagliflozin-metformin + Histrelin
Severity: Moderate
Canagliflozin-metformin and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
GnRH agonists such as histrelin can reduce glucose tolerance and insulin sensitivity, especially in men on androgen deprivation therapy. This may worsen glycemic control in patients with diabetes.
What this interaction means in plain words
Canagliflozin-metformin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Histrelin belongs to Musculoskeletal.
Why it happens
Sex hormone suppression increases insulin resistance, opposing the antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c during histrelin treatment and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Histrelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Histrelin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. GnRH agonists such as histrelin can reduce glucose tolerance and insulin sensitivity, especially in men on androgen deprivation therapy. This may worsen glycemic control in patients with diabetes.
How serious is the interaction between Canagliflozin-metformin and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during histrelin treatment and adjust antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
