Drug interactions
Canagliflozin-metformin + Levofloxacin
Severity: Moderate
Canagliflozin-metformin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients with diabetes taking glucose-lowering drugs. Severe hypoglycemia is more likely in older patients and those with renal impairment.
What this interaction means in plain words
Canagliflozin-metformin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels, increasing insulin release and causing dysglycemia.
What to do
Monitor blood glucose closely during levofloxacin therapy and educate patients on hypoglycemia symptoms. Consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Canagliflozin-metformin with Levofloxacin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients with diabetes taking glucose-lowering drugs. Severe hypoglycemia is more likely in older patients and those with renal impairment.
How serious is the interaction between Canagliflozin-metformin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during levofloxacin therapy and educate patients on hypoglycemia symptoms. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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