Drug interactions
Canagliflozin-metformin + Repaglinide
Severity: Moderate
Canagliflozin-metformin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide stimulates insulin secretion, so adding it to canagliflozin and metformin can increase the risk of hypoglycemia. Patients who skip meals are at particular risk.
What this interaction means in plain words
Canagliflozin-metformin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with repaglinide stimulating insulin secretion from pancreatic beta cells.
What to do
Monitor blood glucose after initiating the combination and lower the repaglinide dose if hypoglycemia occurs. Instruct the patient to take repaglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Canagliflozin-metformin with Repaglinide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide stimulates insulin secretion, so adding it to canagliflozin and metformin can increase the risk of hypoglycemia. Patients who skip meals are at particular risk.
How serious is the interaction between Canagliflozin-metformin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after initiating the combination and lower the repaglinide dose if hypoglycemia occurs. Instruct the patient to take repaglinide only with meals.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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