Drug interactions
Canagliflozin-metformin + Ritonavir
Severity: Moderate
Canagliflozin-metformin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can cause insulin resistance and hyperglycemia, opposing the antidiabetic therapy. It may also induce UGT enzymes and lower canagliflozin exposure. Glycemic control may worsen.
What this interaction means in plain words
Canagliflozin-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir causes protease-inhibitor-related insulin resistance and may induce UGT-mediated canagliflozin metabolism.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic therapy as needed. Consider the canagliflozin dose adjustment per labeling if renal function allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Ritonavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can cause insulin resistance and hyperglycemia, opposing the antidiabetic therapy. It may also induce UGT enzymes and lower canagliflozin exposure. Glycemic control may worsen.
How serious is the interaction between Canagliflozin-metformin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic therapy as needed. Consider the canagliflozin dose adjustment per labeling if renal function allows.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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