Drug interactions
Cisplatin + Tafenoquine
Severity: Moderate
Cisplatin and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits renal cation transporters that take up and eliminate cisplatin. This may raise cisplatin concentrations in renal tubular cells and increase the risk of kidney injury.
What this interaction means in plain words
Cisplatin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Tafenoquine belongs to Anti Parasitic.
Why it happens
In vitro inhibition of OCT2 and MATE transporters by tafenoquine, altering renal tubular handling of cisplatin.
What to do
Avoid the combination where possible; tafenoquine is usually used for malaria prophylaxis or treatment that can be deferred in patients on cisplatin. If unavoidable, monitor serum creatinine and electrolytes closely and apply standard cisplatin nephroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Cisplatin with Tafenoquine?
MediHelp rates the interaction as moderate. Cisplatin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits renal cation transporters that take up and eliminate cisplatin. This may raise cisplatin concentrations in renal tubular cells and increase the risk of kidney injury.
How serious is the interaction between Cisplatin and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; tafenoquine is usually used for malaria prophylaxis or treatment that can be deferred in patients on cisplatin. If unavoidable, monitor serum creatinine and electrolytes closely and apply standard cisplatin nephroprotection.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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