Drug interactions
Canagliflozin-metformin + Thioridazine
Severity: Moderate
Canagliflozin-metformin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine, like other phenothiazines, can impair glucose tolerance and may weaken glycemic control with antidiabetic drugs. Glucose may fall again if the phenothiazine is stopped.
What this interaction means in plain words
Canagliflozin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and impaired insulin release.
What to do
Monitor glucose and HbA1c when starting, adjusting or stopping thioridazine, and titrate antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Thioridazine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine, like other phenothiazines, can impair glucose tolerance and may weaken glycemic control with antidiabetic drugs. Glucose may fall again if the phenothiazine is stopped.
How serious is the interaction between Canagliflozin-metformin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when starting, adjusting or stopping thioridazine, and titrate antidiabetic therapy accordingly.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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