Drug interactions
Canagliflozin-metformin + Tolazamide
Severity: Moderate
Canagliflozin-metformin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining canagliflozin and metformin with tolazamide increases the risk of hypoglycemia through additive glucose lowering. The risk is higher in older adults and in those with reduced renal function or irregular meals.
What this interaction means in plain words
Canagliflozin-metformin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with the sulfonylurea causing glucose-independent insulin release.
What to do
Consider lowering the tolazamide dose when starting canagliflozin-metformin and monitor blood glucose. Counsel the patient on hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Tolazamide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining canagliflozin and metformin with tolazamide increases the risk of hypoglycemia through additive glucose lowering. The risk is higher in older adults and in those with reduced renal function or irregular meals.
How serious is the interaction between Canagliflozin-metformin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the tolazamide dose when starting canagliflozin-metformin and monitor blood glucose. Counsel the patient on hypoglycemia recognition and treatment.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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