Drug interactions
Canagliflozin-metformin + Tranylcypromine
Severity: Moderate
Canagliflozin-metformin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine, a nonselective MAO inhibitor, can enhance the glucose-lowering effect of antidiabetic agents and has been associated with hypoglycemia. Metformin alone has low hypoglycemia risk, so the effect is usually modest.
What this interaction means in plain words
Canagliflozin-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition may increase insulin sensitivity and lower glucose, adding to the effects of antidiabetic drugs.
What to do
Monitor blood glucose when starting or stopping tranylcypromine and adjust the antidiabetic regimen as needed. Teach the patient the symptoms of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Tranylcypromine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine, a nonselective MAO inhibitor, can enhance the glucose-lowering effect of antidiabetic agents and has been associated with hypoglycemia. Metformin alone has low hypoglycemia risk, so the effect is usually modest.
How serious is the interaction between Canagliflozin-metformin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tranylcypromine and adjust the antidiabetic regimen as needed. Teach the patient the symptoms of hypoglycemia.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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