Drug interactions
Canagliflozin-metformin + Verapamil
Severity: Moderate
Canagliflozin-metformin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may inhibit organic cation transporter-mediated hepatic uptake of metformin and reduce its glucose-lowering effect. The effect is variable and usually modest.
What this interaction means in plain words
Canagliflozin-metformin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of OCT1 and possibly other transporters reduces hepatic metformin uptake.
What to do
Monitor glycemic control when verapamil is started or stopped, and increase the metformin dose if control worsens within label limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Canagliflozin-metformin with Verapamil?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may inhibit organic cation transporter-mediated hepatic uptake of metformin and reduce its glucose-lowering effect. The effect is variable and usually modest.
How serious is the interaction between Canagliflozin-metformin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when verapamil is started or stopped, and increase the metformin dose if control worsens within label limits.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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