Drug interactions
Canagliflozin-metformin + Voclosporin
Severity: Moderate
Canagliflozin-metformin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can cause hyperkalemia and reduce renal function. Canagliflozin may also alter potassium, so combined use may increase the risk of hyperkalemia. Reduced renal function would also raise metformin accumulation risk.
What this interaction means in plain words
Canagliflozin-metformin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on potassium homeostasis, with calcineurin inhibitor-related reduced renal potassium excretion and nephrotoxicity.
What to do
Monitor serum potassium and eGFR regularly, and reassess metformin and canagliflozin dosing if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Voclosporin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can cause hyperkalemia and reduce renal function. Canagliflozin may also alter potassium, so combined use may increase the risk of hyperkalemia. Reduced renal function would also raise metformin accumulation risk.
How serious is the interaction between Canagliflozin-metformin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR regularly, and reassess metformin and canagliflozin dosing if renal function declines.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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