Drug interactions
Canakinumab + Cyclosporin
Severity: Moderate
Canakinumab and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function and combining them may raise the risk of infection. Canakinumab may also reverse cytokine-mediated suppression of CYP450 enzymes and alter cyclosporine levels.
What this interaction means in plain words
Canakinumab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canakinumab belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Why it happens
Additive immunosuppression via IL-1 blockade and calcineurin inhibition; IL-1 blockade may normalize CYP450 expression.
What to do
Monitor for signs of infection and check cyclosporine trough levels when canakinumab is started or stopped, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
Frequently asked questions
Can I take Canakinumab with Cyclosporin?
MediHelp rates the interaction as moderate. Canakinumab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress immune function and combining them may raise the risk of infection. Canakinumab may also reverse cytokine-mediated suppression of CYP450 enzymes and alter cyclosporine levels.
How serious is the interaction between Canakinumab and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check cyclosporine trough levels when canakinumab is started or stopped, adjusting the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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