Drug interactions
Candesartan + Celecoxib
Severity: Moderate
Candesartan and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can reduce the antihypertensive effect of candesartan and, together, they can impair renal function, especially in older or volume-depleted patients, with a risk of hyperkalemia.
What this interaction means in plain words
Candesartan and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins lowers glomerular perfusion while ARB blockade of angiotensin II impairs efferent autoregulation and potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the NSAID, and maintain hydration. Avoid in patients with significant renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Celecoxib?
MediHelp rates the interaction as moderate. Candesartan and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can reduce the antihypertensive effect of candesartan and, together, they can impair renal function, especially in older or volume-depleted patients, with a risk of hyperkalemia.
How serious is the interaction between Candesartan and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the NSAID, and maintain hydration. Avoid in patients with significant renal impairment where possible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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