Drug interactions
Candesartan + Diflunisal
Severity: Moderate
Candesartan and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can blunt candesartan's antihypertensive effect and, together, they raise the risk of acute kidney injury and hyperkalemia, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Candesartan and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion, compounded by angiotensin receptor blockade.
What to do
Ensure hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID; avoid in patients with significant renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Diflunisal?
MediHelp rates the interaction as moderate. Candesartan and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can blunt candesartan's antihypertensive effect and, together, they raise the risk of acute kidney injury and hyperkalemia, particularly in elderly or volume-depleted patients.
How serious is the interaction between Candesartan and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID; avoid in patients with significant renal impairment or volume depletion.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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