Drug interactions
Candesartan + Ketoprofen
Severity: Moderate
Candesartan and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can weaken the antihypertensive effect of candesartan and, with an angiotensin receptor blocker, may impair kidney function, particularly in elderly or volume-depleted patients. Potassium may also rise.
What this interaction means in plain words
Candesartan and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins while ARBs lower efferent arteriolar tone, together reducing glomerular filtration and potassium excretion.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing ketoprofen. Avoid regular NSAID use in high-risk patients, especially those also on diuretics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Ketoprofen?
MediHelp rates the interaction as moderate. Candesartan and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can weaken the antihypertensive effect of candesartan and, with an angiotensin receptor blocker, may impair kidney function, particularly in elderly or volume-depleted patients. Potassium may also rise.
How serious is the interaction between Candesartan and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing ketoprofen. Avoid regular NSAID use in high-risk patients, especially those also on diuretics.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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