Drug interactions
Candesartan + Sulindac
Severity: Moderate
Candesartan and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac can reduce the blood pressure lowering effect of candesartan and increases the risk of renal function deterioration, especially in older or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Candesartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Prostaglandin inhibition reduces renal perfusion and causes sodium retention while the ARB lowers efferent arteriolar tone, together compromising glomerular filtration and blunting antihypertensive action.
What to do
Maintain hydration and monitor creatinine, potassium and blood pressure within the first weeks of co-therapy and periodically after. Avoid the combination in patients with volume depletion or advanced renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Sulindac?
MediHelp rates the interaction as moderate. Candesartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac can reduce the blood pressure lowering effect of candesartan and increases the risk of renal function deterioration, especially in older or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Candesartan and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor creatinine, potassium and blood pressure within the first weeks of co-therapy and periodically after. Avoid the combination in patients with volume depletion or advanced renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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