Drug interactions
Candesartan + Voclosporin
Severity: Moderate
Candesartan and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and nephrotoxicity, and candesartan can add to both by lowering glomerular filtration pressure and potassium excretion. This raises the risk of reduced renal function and high potassium.
What this interaction means in plain words
Candesartan and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive hyperkalemic effects and hemodynamic renal effects from calcineurin inhibition and angiotensin receptor blockade.
What to do
Monitor serum potassium and eGFR regularly, especially after starting or changing doses. Adjust the voclosporin dose or the candesartan dose if potassium rises or renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Candesartan with Voclosporin?
MediHelp rates the interaction as moderate. Candesartan and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and nephrotoxicity, and candesartan can add to both by lowering glomerular filtration pressure and potassium excretion. This raises the risk of reduced renal function and high potassium.
How serious is the interaction between Candesartan and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR regularly, especially after starting or changing doses. Adjust the voclosporin dose or the candesartan dose if potassium rises or renal function declines.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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