Drug interactions
Candesartan-hydrochlorothiazide + Chlorpropamide
Severity: Moderate
Candesartan-hydrochlorothiazide and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and impair glycemic control, which may reduce the effectiveness of chlorpropamide. Thiazide-induced hyponatremia may also add to the hyponatremia risk already seen with chlorpropamide.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Thiazides cause hypokalemia and reduced insulin secretion and sensitivity, opposing sulfonylurea glucose lowering.
What to do
Monitor blood glucose and HbA1c after starting or changing the thiazide and adjust the antidiabetic dose if needed. Check serum sodium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Chlorpropamide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and impair glycemic control, which may reduce the effectiveness of chlorpropamide. Thiazide-induced hyponatremia may also add to the hyponatremia risk already seen with chlorpropamide.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the thiazide and adjust the antidiabetic dose if needed. Check serum sodium periodically.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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