Drug interactions
Candesartan-hydrochlorothiazide + Cyclophosphamide
Severity: Moderate
Candesartan-hydrochlorothiazide and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase the myelosuppressive effect of cyclophosphamide, causing deeper or more prolonged neutropenia. Volume depletion from the diuretic may add to chemotherapy toxicity.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Cyclophosphamide belongs to Oncology.
Why it happens
Thiazides are thought to reduce renal clearance of cyclophosphamide or its metabolites, increasing marrow exposure.
What to do
Monitor complete blood counts closely during cyclophosphamide cycles and maintain hydration. Consider an alternative antihypertensive if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Cyclophosphamide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may increase the myelosuppressive effect of cyclophosphamide, causing deeper or more prolonged neutropenia. Volume depletion from the diuretic may add to chemotherapy toxicity.
How serious is the interaction between Candesartan-hydrochlorothiazide and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during cyclophosphamide cycles and maintain hydration. Consider an alternative antihypertensive if marked myelosuppression occurs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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