Drug interactions
Candesartan-hydrochlorothiazide + Dobutamine
Severity: Moderate
Candesartan-hydrochlorothiazide and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine stimulates beta-2 receptors and can shift potassium into cells, and hydrochlorothiazide also wastes potassium. Together they can cause clinically relevant hypokalemia and arrhythmias, especially in acutely ill cardiac patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Dobutamine belongs to Cardiovascular.
Why it happens
Additive lowering of serum potassium through beta-adrenergic intracellular shift and thiazide renal potassium loss.
What to do
Monitor serum potassium and ECG during dobutamine infusion in patients taking this combination. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Dobutamine?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine stimulates beta-2 receptors and can shift potassium into cells, and hydrochlorothiazide also wastes potassium. Together they can cause clinically relevant hypokalemia and arrhythmias, especially in acutely ill cardiac patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dobutamine infusion in patients taking this combination. Replace potassium and magnesium as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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