Drug interactions
Candesartan-hydrochlorothiazide + Enoxaparin
Severity: Moderate
Candesartan-hydrochlorothiazide and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress aldosterone secretion and cause hyperkalemia, which may be amplified by an angiotensin receptor blocker. The effect is mostly seen with prolonged use or in patients with renal impairment or diabetes.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to the potassium-retaining effect of angiotensin receptor blockade.
What to do
Monitor serum potassium in patients on prolonged enoxaparin with candesartan, especially with renal impairment or diabetes. Treat hyperkalemia if it appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Enoxaparin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress aldosterone secretion and cause hyperkalemia, which may be amplified by an angiotensin receptor blocker. The effect is mostly seen with prolonged use or in patients with renal impairment or diabetes.
How serious is the interaction between Candesartan-hydrochlorothiazide and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on prolonged enoxaparin with candesartan, especially with renal impairment or diabetes. Treat hyperkalemia if it appears.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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