Drug interactions
Candesartan-hydrochlorothiazide + Epoprostenol
Severity: Moderate
Candesartan-hydrochlorothiazide and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator and can add to the blood pressure-lowering effect of antihypertensive combinations containing a diuretic and an angiotensin receptor blocker. Symptomatic hypotension may occur, especially with volume depletion.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure and volume status when starting or adjusting epoprostenol, and reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Candesartan-hydrochlorothiazide and Epoprostenol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Epoprostenol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator and can add to the blood pressure-lowering effect of antihypertensive combinations containing a diuretic and an angiotensin receptor blocker. Symptomatic hypotension may occur, especially with volume depletion.
How serious is the interaction between Candesartan-hydrochlorothiazide and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or adjusting epoprostenol, and reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
