Drug interactions
Candesartan-hydrochlorothiazide + Fludrocortisone
Severity: Moderate
Candesartan-hydrochlorothiazide and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity and, with a thiazide, can cause marked potassium loss. It also opposes the antihypertensive effect through sodium and fluid retention.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting, with mineralocorticoid-driven sodium retention opposing blood pressure lowering.
What to do
Monitor serum potassium and blood pressure regularly and supplement potassium if needed. Reassess the need for both drugs if hypokalemia or hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Fludrocortisone?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity and, with a thiazide, can cause marked potassium loss. It also opposes the antihypertensive effect through sodium and fluid retention.
How serious is the interaction between Candesartan-hydrochlorothiazide and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure regularly and supplement potassium if needed. Reassess the need for both drugs if hypokalemia or hypertension develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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