Drug interactions
Candesartan-hydrochlorothiazide + Meloxicam
Severity: Moderate
Candesartan-hydrochlorothiazide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can reduce the blood pressure control achieved with candesartan and hydrochlorothiazide. Combined use increases the risk of renal function decline and hyperkalemia, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID-mediated prostaglandin inhibition reduces renal blood flow and promotes fluid retention when the RAS is blocked and a diuretic is on board.
What to do
Use the lowest effective meloxicam dose for the shortest time with adequate hydration. Monitor blood pressure, serum creatinine, and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Meloxicam?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam can reduce the blood pressure control achieved with candesartan and hydrochlorothiazide. Combined use increases the risk of renal function decline and hyperkalemia, particularly in elderly or volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose for the shortest time with adequate hydration. Monitor blood pressure, serum creatinine, and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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