Drug interactions
Candesartan-hydrochlorothiazide + Quinine
Severity: Minor
Candesartan-hydrochlorothiazide and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide could theoretically compete with quinine for renal tubular secretion and slightly raise quinine levels. Clinically meaningful changes are not well documented. Both drugs can also affect electrolytes and QT interval, which is the more relevant concern.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Possible competition for renal tubular secretion; the pharmacokinetic effect is not well established.
What to do
No dose change is usually needed; check potassium and magnesium and consider ECG monitoring if quinine is given to patients with risk of QT prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Quinine?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide could theoretically compete with quinine for renal tubular secretion and slightly raise quinine levels. Clinically meaningful changes are not well documented. Both drugs can also affect electrolytes and QT interval, which is the more relevant concern.
How serious is the interaction between Candesartan-hydrochlorothiazide and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; check potassium and magnesium and consider ECG monitoring if quinine is given to patients with risk of QT prolongation.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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