Drug interactions
Candesartan-hydrochlorothiazide + Timolol
Severity: Moderate
Candesartan-hydrochlorothiazide and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol, even as eye drops, can be absorbed systemically and add to the blood pressure lowering and bradycardic effects of candesartan and hydrochlorothiazide. Beta-blockers can also slightly raise potassium. The effect is usually modest and manageable.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect, and beta-blockade can mildly impair cellular potassium uptake.
What to do
Monitor blood pressure, heart rate and serum potassium. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Timolol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol, even as eye drops, can be absorbed systemically and add to the blood pressure lowering and bradycardic effects of candesartan and hydrochlorothiazide. Beta-blockers can also slightly raise potassium. The effect is usually modest and manageable.
How serious is the interaction between Candesartan-hydrochlorothiazide and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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