Drug interactions
Candesartan-hydrochlorothiazide + Triamterene
Severity: Major
Candesartan-hydrochlorothiazide and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan and triamterene both promote potassium retention and can cause hyperkalemia, only partly offset by hydrochlorothiazide. Renal impairment greatly increases the risk.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade lowers aldosterone effect while triamterene blocks ENaC, giving additive potassium retention.
What to do
Monitor serum potassium and renal function at baseline, within the first week, and periodically. Avoid potassium supplements and stop triamterene if hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Triamterene?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Candesartan and triamterene both promote potassium retention and can cause hyperkalemia, only partly offset by hydrochlorothiazide. Renal impairment greatly increases the risk.
How serious is the interaction between Candesartan-hydrochlorothiazide and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at baseline, within the first week, and periodically. Avoid potassium supplements and stop triamterene if hyperkalemia occurs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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