Drug interactions
Candesartan-hydrochlorothiazide + Valsartan
Severity: Major
Candesartan-hydrochlorothiazide and Valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using candesartan with valsartan duplicates angiotensin receptor blockade without added benefit. It raises the risk of hypotension, hyperkalemia and renal dysfunction.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II receptor blockade giving additive hypotensive, renal and potassium-retaining effects.
What to do
Avoid using two ARBs together and keep to one agent. If already combined, stop one drug and monitor potassium, creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Valsartan?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using candesartan with valsartan duplicates angiotensin receptor blockade without added benefit. It raises the risk of hypotension, hyperkalemia and renal dysfunction.
How serious is the interaction between Candesartan-hydrochlorothiazide and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together and keep to one agent. If already combined, stop one drug and monitor potassium, creatinine and blood pressure.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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