Drug interactions
Cannabidiol + Celecoxib
Severity: Moderate
Cannabidiol and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9, the main enzyme clearing celecoxib, which could raise celecoxib concentrations. Higher exposure may increase gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Cannabidiol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Celecoxib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated celecoxib metabolism by cannabidiol.
What to do
Monitor for celecoxib adverse effects and consider a lower celecoxib dose, particularly with high cannabidiol doses or in CYP2C9 poor metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Celecoxib?
MediHelp rates the interaction as moderate. Cannabidiol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may inhibit CYP2C9, the main enzyme clearing celecoxib, which could raise celecoxib concentrations. Higher exposure may increase gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Cannabidiol and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for celecoxib adverse effects and consider a lower celecoxib dose, particularly with high cannabidiol doses or in CYP2C9 poor metabolizers.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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