Drug interactions
Cannabidiol + Chloramphenicol
Severity: Moderate
Cannabidiol and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and CYP2C19 and increase cannabidiol exposure, which can cause somnolence, sedation and liver enzyme elevation.
What this interaction means in plain words
Cannabidiol and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 and CYP2C19 metabolism of cannabidiol.
What to do
Monitor for sedation and consider reducing the cannabidiol dose during chloramphenicol therapy. Check liver enzymes if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Chloramphenicol?
MediHelp rates the interaction as moderate. Cannabidiol and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and CYP2C19 and increase cannabidiol exposure, which can cause somnolence, sedation and liver enzyme elevation.
How serious is the interaction between Cannabidiol and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and consider reducing the cannabidiol dose during chloramphenicol therapy. Check liver enzymes if symptoms arise.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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