Drug interactions
Cannabidiol + Clomipramine
Severity: Moderate
Cannabidiol and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which helps convert clomipramine to its active metabolite, and also inhibits CYP2D6 to some extent. Clomipramine exposure may rise, increasing anticholinergic, sedative, seizure and cardiac adverse effects.
What this interaction means in plain words
Cannabidiol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 (and possibly CYP2D6) by cannabidiol reduces clomipramine metabolism.
What to do
Monitor for tricyclic toxicity and consider lowering the clomipramine dose when cannabidiol is started. Check plasma levels or an ECG if symptoms or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cannabidiol and Clomipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Clomipramine?
MediHelp rates the interaction as moderate. Cannabidiol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19, which helps convert clomipramine to its active metabolite, and also inhibits CYP2D6 to some extent. Clomipramine exposure may rise, increasing anticholinergic, sedative, seizure and cardiac adverse effects.
How serious is the interaction between Cannabidiol and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider lowering the clomipramine dose when cannabidiol is started. Check plasma levels or an ECG if symptoms or risk factors are present.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
