Drug interactions
Cannabidiol + Clopidogrel
Severity: Moderate
Cannabidiol and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which converts clopidogrel to its active metabolite, so antiplatelet activity may be reduced. This might lead to less protection from thrombotic events.
What this interaction means in plain words
Cannabidiol and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clopidogrel belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19 by cannabidiol reduces bioactivation of clopidogrel.
What to do
Consider an antiplatelet not dependent on CYP2C19, such as prasugrel, in high-risk patients. Otherwise, watch for thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cannabidiol and Clopidogrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Other interactions of Clopidogrel
Frequently asked questions
Can I take Cannabidiol with Clopidogrel?
MediHelp rates the interaction as moderate. Cannabidiol and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19, which converts clopidogrel to its active metabolite, so antiplatelet activity may be reduced. This might lead to less protection from thrombotic events.
How serious is the interaction between Cannabidiol and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antiplatelet not dependent on CYP2C19, such as prasugrel, in high-risk patients. Otherwise, watch for thrombotic events.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Sodium valproate, Tacrolimus. The full list is on the Cannabidiol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
