Drug interactions
Cannabidiol + Diclofenac
Severity: Minor
Cannabidiol and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit CYP2C9, the main enzyme metabolizing diclofenac, and may raise diclofenac concentrations. This could increase NSAID adverse effects such as GI, renal and cardiovascular events.
What this interaction means in plain words
Cannabidiol and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Diclofenac belongs to Musculoskeletal.
Why it happens
Cannabidiol inhibition of CYP2C9-mediated diclofenac hydroxylation.
What to do
Use the lowest effective diclofenac dose and monitor for NSAID adverse effects. Consider diclofenac dose reduction if toxicity emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Diclofenac?
MediHelp rates the interaction as minor. Cannabidiol and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol can inhibit CYP2C9, the main enzyme metabolizing diclofenac, and may raise diclofenac concentrations. This could increase NSAID adverse effects such as GI, renal and cardiovascular events.
How serious is the interaction between Cannabidiol and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for NSAID adverse effects. Consider diclofenac dose reduction if toxicity emerges.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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