Drug interactions
Cannabidiol + Fluoxetine
Severity: Moderate
Cannabidiol and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2C19 and can raise cannabidiol's active metabolite exposure, while cannabidiol may inhibit CYP2C19 and CYP2C9 and raise fluoxetine levels. This may increase sedation, somnolence and other adverse effects of both drugs.
What this interaction means in plain words
Cannabidiol and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Fluoxetine belongs to Central Nervous System.
Why it happens
Mutual inhibition of hepatic CYP2C19 and CYP2C9-mediated metabolism.
What to do
Monitor for sedation and fluoxetine adverse effects, and consider lowering the cannabidiol dose if adverse effects emerge. Adjust fluoxetine dose according to tolerability and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Fluoxetine?
MediHelp rates the interaction as moderate. Cannabidiol and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine inhibits CYP2C19 and can raise cannabidiol's active metabolite exposure, while cannabidiol may inhibit CYP2C19 and CYP2C9 and raise fluoxetine levels. This may increase sedation, somnolence and other adverse effects of both drugs.
How serious is the interaction between Cannabidiol and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and fluoxetine adverse effects, and consider lowering the cannabidiol dose if adverse effects emerge. Adjust fluoxetine dose according to tolerability and clinical response.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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