Drug interactions
Cannabidiol + Hydrochlorothiazide-losartan
Severity: Minor
Cannabidiol and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9 and reduce conversion of losartan to its active metabolite. The result could be altered antihypertensive effect, though clinical significance is uncertain.
What this interaction means in plain words
Cannabidiol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible CYP2C9 inhibition by cannabidiol, reducing losartan activation to E-3174.
What to do
Monitor blood pressure when cannabidiol is started, changed or stopped, and adjust losartan if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Cannabidiol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C9 and reduce conversion of losartan to its active metabolite. The result could be altered antihypertensive effect, though clinical significance is uncertain.
How serious is the interaction between Cannabidiol and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when cannabidiol is started, changed or stopped, and adjust losartan if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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