Drug interactions
Cannabidiol + Itraconazole
Severity: Moderate
Cannabidiol and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol is metabolized by CYP3A4 and CYP2C19, and itraconazole may increase its exposure. This can increase somnolence, diarrhea and liver enzyme elevations.
What this interaction means in plain words
Cannabidiol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, reducing cannabidiol clearance.
What to do
Monitor for sedation and liver enzyme elevations, and reduce the cannabidiol dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Itraconazole?
MediHelp rates the interaction as moderate. Cannabidiol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol is metabolized by CYP3A4 and CYP2C19, and itraconazole may increase its exposure. This can increase somnolence, diarrhea and liver enzyme elevations.
How serious is the interaction between Cannabidiol and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and liver enzyme elevations, and reduce the cannabidiol dose if adverse effects occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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