Drug interactions
Cannabidiol + Lapatinib
Severity: Minor
Cannabidiol and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can inhibit CYP3A4 and may raise cannabidiol concentrations. Higher exposure may increase sedation, somnolence and other dose-related adverse effects.
What this interaction means in plain words
Cannabidiol and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated cannabidiol metabolism by lapatinib.
What to do
Monitor for excess sedation, dizziness and liver enzyme elevations. Reduce the cannabidiol dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Lapatinib?
MediHelp rates the interaction as minor. Cannabidiol and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib can inhibit CYP3A4 and may raise cannabidiol concentrations. Higher exposure may increase sedation, somnolence and other dose-related adverse effects.
How serious is the interaction between Cannabidiol and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and liver enzyme elevations. Reduce the cannabidiol dose if adverse effects develop.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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