Drug interactions
Cannabidiol + Lidocaine-prilocaine
Severity: Minor
Cannabidiol and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can alter CYP1A2 activity, which contributes to lidocaine metabolism. With topical lidocaine-prilocaine, systemic exposure is low, so any clinical effect is unlikely unless large areas or prolonged use are involved.
What this interaction means in plain words
Cannabidiol and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Lidocaine-prilocaine belongs to Genitourinary.
Why it happens
Cannabidiol may inhibit or induce CYP1A2 and other CYP enzymes, altering lidocaine clearance.
What to do
No action is needed for typical topical use. With large-area or prolonged application, monitor for signs of lidocaine toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Cannabidiol and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol can alter CYP1A2 activity, which contributes to lidocaine metabolism. With topical lidocaine-prilocaine, systemic exposure is low, so any clinical effect is unlikely unless large areas or prolonged use are involved.
How serious is the interaction between Cannabidiol and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for typical topical use. With large-area or prolonged application, monitor for signs of lidocaine toxicity.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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