Drug interactions
Cannabidiol + Losartan
Severity: Minor
Cannabidiol and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9, which activates losartan to its carboxylic acid metabolite. Losartan parent exposure could rise while active metabolite formation falls, so the net effect on blood pressure is uncertain.
What this interaction means in plain words
Cannabidiol and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Losartan belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP2C9-mediated losartan metabolism by cannabidiol.
What to do
Monitor blood pressure and adjust losartan dose according to response when cannabidiol is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Losartan?
MediHelp rates the interaction as minor. Cannabidiol and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C9, which activates losartan to its carboxylic acid metabolite. Losartan parent exposure could rise while active metabolite formation falls, so the net effect on blood pressure is uncertain.
How serious is the interaction between Cannabidiol and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust losartan dose according to response when cannabidiol is started or stopped.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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