Drug interactions
Cannabidiol + Metaxalone
Severity: Minor
Cannabidiol and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can affect CYP1A2 activity, and metaxalone is partly metabolized by CYP1A2 among other enzymes. Exposure to metaxalone could change modestly, and both drugs can cause drowsiness.
What this interaction means in plain words
Cannabidiol and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Cannabidiol may inhibit or induce CYP1A2, altering metaxalone metabolism, plus additive sedation.
What to do
Monitor for increased sedation or reduced effect and adjust the metaxalone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Metaxalone?
MediHelp rates the interaction as minor. Cannabidiol and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol can affect CYP1A2 activity, and metaxalone is partly metabolized by CYP1A2 among other enzymes. Exposure to metaxalone could change modestly, and both drugs can cause drowsiness.
How serious is the interaction between Cannabidiol and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or reduced effect and adjust the metaxalone dose if needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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