Drug interactions
Cannabidiol + Nicardipine
Severity: Minor
Cannabidiol and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol is cleared partly by CYP2C19 and CYP3A4, and nicardipine can inhibit CYP2C19 among other enzymes. Cannabidiol exposure may rise, increasing somnolence, sedation and liver enzyme elevations.
What this interaction means in plain words
Cannabidiol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19 and CYP3A4 metabolism of cannabidiol by nicardipine.
What to do
Monitor for excess sedation and liver enzyme elevation, and reduce the cannabidiol dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Nicardipine?
MediHelp rates the interaction as minor. Cannabidiol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol is cleared partly by CYP2C19 and CYP3A4, and nicardipine can inhibit CYP2C19 among other enzymes. Cannabidiol exposure may rise, increasing somnolence, sedation and liver enzyme elevations.
How serious is the interaction between Cannabidiol and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and liver enzyme elevation, and reduce the cannabidiol dose if adverse effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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